Usage of Mesenchymal Stem Cells

MSCs, are multipotent stem cells that can differentiate into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells) and adipocytes (fat cells).

Bone Cells
  • Mesenchymal stem cells are capable of self-renewal and differentiation into various connective tissue lineages.
  • Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum, trabecular bone, adipose tissue, synovium, skeletal muscle and deciduous teeth
  • These cells have the capacity to differentiate into cells of connective tissue lineages, including bone, fat, cartilage and muscle.
  • MSCs can also express phenotypic characteristics of endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells.
  • When induced into the infarcted heart, MSCs prevent deleterious remodeling and improve recovery
  • Clinical use of cultured human MSCs (hMSCs) has begun for cancer patients, and recipients have received autologous or allogeneic MSCs
  • MSCs can be used allogeneically, delivered systemically, and differentiate into a cardiomyocyte-like phenotype when implanted in healthy myocardium
  • MSCs can be readily transduced by a variety of vectors and maintain transgene expression after in vivo differentiation.
Background Image