Usage of Mesenchymal Stem Cells
MSCs, are multipotent stem cells that can differentiate into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells) and adipocytes (fat cells).
- Mesenchymal stem cells are capable of self-renewal and differentiation into various connective tissue lineages.
- Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum, trabecular bone, adipose tissue, synovium, skeletal muscle and deciduous teeth
- These cells have the capacity to differentiate into cells of connective tissue lineages, including bone, fat, cartilage and muscle.
- MSCs can also express phenotypic characteristics of endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells.
- When induced into the infarcted heart, MSCs prevent deleterious remodeling and improve recovery
- Clinical use of cultured human MSCs (hMSCs) has begun for cancer patients, and recipients have received autologous or allogeneic MSCs
- MSCs can be used allogeneically, delivered systemically, and differentiate into a cardiomyocyte-like phenotype when implanted in healthy myocardium
- MSCs can be readily transduced by a variety of vectors and maintain transgene expression after in vivo differentiation.